SCHEMBL2314977

SCHEMBL2314977

C=CC(=O)OCCc1ccc(-c2ccc(N(c3ccccc3)c3ccccc3)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.51
HCAR2 Q8TDS4 1/20 0.48
AKR1B10 O60218 4/20 0.46
AKR1B1 P15121 4/20 0.46
MAOB P27338 1/20 0.42
ALDH1A1 P00352 3/20 0.40
TP53 P04637 3/20 0.40
TSHR P16473 3/20 0.40
HIF1A Q16665 3/20 0.40
HSD17B10 Q99714 3/20 0.40
ALOX5 P09917 3/20 0.40
APP P05067 2/20 0.40
CYP3A4 P08684 2/20 0.40
ALOX15 P16050 2/20 0.40
ALOX12 P18054 2/20 0.40
MAPK1 P28482 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
GMNN O75496 1/20 0.40
EGFR P00533 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13007033 1.00 THRB (0.51) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL9915739 0.99 THRB (0.50) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL13006150 0.97 THRB (0.49) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL12214253 0.97 THRB (0.51) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL9915737 0.96 THRB (0.55) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL20733442 0.96 THRB (0.55) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL2308061 0.94 THRB (0.46) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL13777525 0.94 THRB (0.52) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL13777519 0.94 THRB (0.48) THRBHCAR2AKR1B10AKR1B1MAOB
SCHEMBL2609793 0.93 AKR1B10 (0.49) THRBHCAR2AKR1B10AKR1B1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4246235-A1 PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2023-09-20 EP disclosed
US-20230288867-A1 PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2023-09-14 US disclosed
US-20230288867-A1 PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2023-09-14 US disclosed
US-11703773-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2023-07-18 US disclosed
US-11703773-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2023-07-18 US disclosed
US-11415904-B2 Image forming method and image forming system Konica Minolta, Inc. (JP) 2022-08-16 US disclosed
US-20210318632-A1 IMAGE FORMING METHOD AND IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2021-10-14 US disclosed
US-8486595-B2 Image bearing member, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2013-07-16 US disclosed
US-8383305-B2 Image forming apparatus RICOH COMPANY, LTD. (JP) 2013-02-26 US disclosed
US-8273513-B2 Image forming apparatus, process cartridge, and image bearing member RICOH COMPANY, LIMITED (JP) 2012-09-25 US disclosed
US-20110286777-A1 LUBRICANT AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING SAME RICOH COMPANY, LTD. (JP) 2011-11-24 US disclosed
EP-2000855-B1 Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge RICOH CO LTD (JP) 2011-08-03 EP disclosed
US-20110059393-A1 IMAGE BEARING MEMBER, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2011-03-10 US disclosed
US-20110020740-A1 IMAGE FORMING APPARATUS RICOH COMPANY, LTD (JP) 2011-01-27 US disclosed
US-20100330475-A1 IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE BEARING MEMBER RICOH COMPANY LIMITED (JP) 2010-12-30 US disclosed
US-20090185821-A1 Electrophotographic photoreceptor, and image formihg appratus and process cartridge using same RICOH COMPANY, LTD (JP) 2009-07-23 US disclosed
US-20080304867-A1 Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge RICOH COMPANY, LTD. 2008-12-11 US disclosed
EP-2000855-A1 Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge Ricoh Company, Ltd. (JP) 2008-12-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080304867-A1 Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge KDM1A, C9, JMJD6 THRB 4693/4885HCAR2 1926/4885AKR1B10 256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.