Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 8/20 | 0.42 |
| ▸ | ABL1 | P00519 | 5/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553605 | 0.95 | FGFR1 (0.45) | FGFR1FGFR2SRCABL1HCK | |
| SCHEMBL30363553 | 0.84 | RET (0.49) | FGFR1FGFR2SRCABL1HCK | |
| SCHEMBL21528023 | 0.84 | RET (0.49) | FGFR1FGFR2SRCABL1HCK | |
| SCHEMBL23150480 | 0.82 | ABL1 (0.41) | SRCABL1HCKBTKLCK | |
| SCHEMBL23150484 | 0.81 | ABL1 (0.47) | FGFR1FGFR2SRCABL1HCK | |
| SCHEMBL19294576 | 0.78 | ABL1 (0.43) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL19283030 | 0.78 | ABL1 (0.39) | SRCABL1HCKPIK3CDPIK3CA | |
| SCHEMBL20553647 | 0.78 | ABL1 (0.43) | SRCABL1HCKLCKRET | |
| SCHEMBL30405960 | 0.78 | ABL1 (0.43) | SRCABL1HCKLCKRET | |
| SCHEMBL20553041 | 0.76 | ABL1 (0.48) | FGFR1FGFR2SRCABL1HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | FGFR1 1411/4885FGFR2 1868/4885SRC 579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.