Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.49 |
| ▸ | KDR | P35968 | 11/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528023 | 1.00 | RET (0.49) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL30405204 | 0.90 | RET (0.51) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL29669709 | 0.89 | RET (0.55) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL23157800 | 0.89 | RET (0.55) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL29939196 | 0.84 | RET (0.48) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL19294573 | 0.84 | RET (0.48) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL23150479 | 0.84 | FGFR1 (0.45) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL23158015 | 0.84 | RET (0.53) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL29669798 | 0.84 | RET (0.53) | RETKDRFGFR1FGFR2SRC | |
| SCHEMBL20553605 | 0.84 | FGFR1 (0.45) | RETKDRFGFR1FGFR2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| EP-3788049-B1 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |