Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.31 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3093516 | 0.88 | MAPT (0.34) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL28071350 | 0.84 | CHRM2 (0.33) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL8436600 | 0.84 | CHRNB2 (0.32) | — | |
| SCHEMBL690050 | 0.81 | MAPT (0.38) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL659836 | 0.81 | MAPT (0.38) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL661356 | 0.81 | MAPT (0.38) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL167002 | 0.81 | SSTR4 (0.34) | MAPTPKMSLC6A1GABRA5GABRB2 | |
| SCHEMBL7501322 | 0.80 | MAPT (0.47) | MAPTPKM | |
| SCHEMBL19973194 | 0.79 | MAPT (0.33) | MAPTPKM | |
| SCHEMBL1555124 | 0.78 | GABRR1 (0.35) | GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034541-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2022-08-03 | — | — | EP | disclosed |
| WO-2021058444-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-04-01 | — | — | WO | disclosed |