Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | PRNP | P04156 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12009674 | 0.86 | HPGD (0.52) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL2162296 | 0.84 | HPGD (0.52) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL7211399 | 0.84 | HPGD (0.54) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL18782597 | 0.84 | HPGD (0.50) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL2325077 | 0.84 | HPGD (0.50) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL17813071 | 0.84 | HPGD (0.50) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL2162352 | 0.83 | HPGD (0.51) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL317871 | 0.83 | HPGD (0.55) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL2162982 | 0.83 | HPGD (0.55) | LMNARXFP1ALDH1A1PRNPRECQL | |
| SCHEMBL27621806 | 0.83 | HPGD (0.55) | LMNARXFP1ALDH1A1PRNPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024114782-A1 | SMALL-MOLECULE MODULATORS OF SPIKE PROTEIN | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-06-06 | — | — | WO | disclosed |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | disclosed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | disclosed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | disclosed |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-12-06 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | disclosed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | disclosed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2348843-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of the Holy Ghost (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039792-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-04-08 | — | — | WO | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | LMNA 4659/4885RXFP1 915/4885ALDH1A1 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.