Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488177 | 0.83 | KDM1A (0.41) | NPC1LMNAHRH3CARM1PRMT6 | |
| SCHEMBL23158162 | 0.79 | LMNA (0.35) | NPC1LMNAHRH3CARM1PRMT6 | |
| SCHEMBL14385014 | 0.79 | CARM1 (0.50) | LMNAHRH3CARM1PRMT6SIGMAR1 | |
| SCHEMBL12912306 | 0.78 | CYP2D6 (0.43) | NPC1LMNAHRH3HTR2AHTR2C | |
| SCHEMBL23158208 | 0.78 | NPC1 (0.38) | NPC1LMNALTA4HKDM4E | |
| SCHEMBL23158168 | 0.78 | HRH2 (0.33) | HRH3SIGMAR1LTA4H | |
| SCHEMBL25621681 | 0.77 | NPC1 (0.53) | NPC1LMNAHRH3CARM1PRMT6 | |
| SCHEMBL13656275 | 0.77 | KCNH2 (0.41) | NPC1LMNAHRH3CARM1PRMT6 | |
| SCHEMBL12714801 | 0.77 | DRD2 (0.47) | HRH3 | |
| SCHEMBL18776050 | 0.76 | NPC1 (0.42) | NPC1CARM1PRMT6SIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021057832-A1 | KRAS MUTANT PROTEIN INHIBITOR | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-04-01 | — | — | WO | disclosed |