Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445466 | 0.87 | ALDH1A1 (0.54) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL12301210 | 0.87 | ALDH1A1 (0.54) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2443199 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2448634 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2450810 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2443247 | 0.77 | ALDH1A1 (0.55) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2442636 | 0.75 | ALDH1A1 (0.52) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2446049 | 0.74 | ALDH1A1 (0.54) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2442095 | 0.74 | ALDH1A1 (0.54) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2447811 | 0.74 | ALDH1A1 (0.54) | ALDH1A1MAPK1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230471-A1 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-09-22 | — | — | US | disclosed |
| EP-2352733-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | Merck Patent GmbH (DE) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010060532-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230471-A1 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN | ENPP2, TPX2, TPD52L2 | ALDH1A1 4584/4885MAPK1 3988/4885KMT2A 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.