Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 13/20 | 0.56 |
| ▸ | ADCY8 | P40145 | 10/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798510 | 0.84 | ADCY1 (0.78) | ADCY1ADCY8HTR2B | |
| SCHEMBL20657964 | 0.82 | ADCY1 (0.75) | ADCY1ADCY8HTR2BKDM4ENPSR1 | |
| SCHEMBL23160938 | 0.81 | ADCY1 (0.54) | ADCY1ADCY8HTR2BKDM4ENPSR1 | |
| SCHEMBL23160948 | 0.80 | ADCY1 (0.74) | ADCY1ADCY8HTR2BKDM4ENPSR1 | |
| SCHEMBL23160969 | 0.79 | ADCY1 (0.61) | ADCY1ADCY8HTR2BKDM4EHTT | |
| SCHEMBL23160941 | 0.76 | ADCY1 (0.71) | ADCY1ADCY8HTR2BKDM4EALDH1A1 | |
| SCHEMBL23160963 | 0.76 | ADCY1 (0.74) | ADCY1ADCY8HTR2BKDM4ENPSR1 | |
| SCHEMBL23160940 | 0.75 | ADCY8 (0.68) | ADCY1ADCY8HTR2B | |
| SCHEMBL23160937 | 0.75 | ADCY1 (0.72) | ADCY1ADCY8HTR2BMEN1KMT2A | |
| SCHEMBL20657978 | 0.75 | ADCY1 (0.74) | ADCY1ADCY8HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250084-A1 | PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2023-08-10 | — | — | US | disclosed |
| US-11690844-B2 | Pyrazolyl pyrimidinone compounds and the uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2023-07-04 | — | — | US | disclosed |
| US-20210100797-A1 | PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2021-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11690844-B2 | Pyrazolyl pyrimidinone compounds and the uses thereof | CAP1, ADCY1, ADCYAP1R1 | ADCY1 2/4885ADCY8 9/4885HTR2B 1487/4885 |
| US-20230250084-A1 | PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF | CAP1, ADCY1, ADCYAP1R1 | ADCY1 2/4885ADCY8 9/4885HTR2B 1487/4885 |
| US-20210100797-A1 | PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF | CAP1, ADCY1, ADCYAP1R1 | ADCY1 2/4885ADCY8 9/4885HTR2B 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.