Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445526 | 0.81 | LMNA (0.39) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL2324033 | 0.78 | POLB (0.42) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL2359997 | 0.74 | F10 (0.39) | KMT2AMEN1ALDH1A1MAPK1NPC1 | |
| SCHEMBL12301091 | 0.71 | LMNA (0.43) | KMT2AALDH1A1POLBMAPTL3MBTL1 | |
| SCHEMBL2320130 | 0.64 | LMNA (0.40) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL2451497 | 0.64 | ALDH1A1 (0.46) | KMT2AALDH1A1POLBMAPTL3MBTL1 | |
| SCHEMBL2319059 | 0.61 | LMNA (0.43) | KMT2AALDH1A1POLBMAPTL3MBTL1 | |
| SCHEMBL2317680 | 0.58 | KDM4E (0.44) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL2319410 | 0.58 | LMNA (0.47) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL2316929 | 0.58 | ALDH1A1 (0.46) | KMT2AALDH1A1POLBMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352733-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | Merck Patent GmbH (DE) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010060532-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |