Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23163942 | 0.95 | POLB (0.48) | ALDH1A1POLBHTTTP53PTGER4 | |
| SCHEMBL23163938 | 0.95 | POLB (0.48) | ALDH1A1POLBHTTTP53PTGER4 | |
| SCHEMBL23164065 | 0.93 | ALDH1A1 (0.47) | ALDH1A1POLBHTTTP53FFAR1 | |
| SCHEMBL23164063 | 0.93 | ALDH1A1 (0.47) | ALDH1A1POLBHTTTP53FFAR1 | |
| SCHEMBL23163961 | 0.91 | RXRA (0.52) | ALDH1A1POLBHTTTP53RAB9A | |
| SCHEMBL23163958 | 0.91 | RXRA (0.52) | ALDH1A1POLBHTTTP53RAB9A | |
| SCHEMBL23163611 | 0.89 | ALDH1A1 (0.47) | ALDH1A1POLBHTTTP53FFAR1 | |
| SCHEMBL23163608 | 0.89 | ALDH1A1 (0.47) | ALDH1A1POLBHTTTP53FFAR1 | |
| SCHEMBL23163680 | 0.85 | POLB (0.48) | ALDH1A1POLBHTTTP53PTGER4 | |
| SCHEMBL27078201 | 0.84 | ALDH1A1 (0.49) | ALDH1A1POLBHTTTP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4038052-B1 | PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS | DOMAIN THERAPEUTICS (FR) | 2024-02-07 | — | — | EP | disclosed |
| CN-114555573-A | Prostaglandin E2(PGE2)EP4Receptor antagonists | 多曼治疗学公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021064189-A2 | PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS | DOMAIN THERAPEUTICS (FR) | 2021-04-08 | — | — | WO | disclosed |