SCHEMBL2316672

SCHEMBL2316672

O=C(O)N1CC(OCc2ccccc2)CC1CO

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 2/20 0.54
CTSL P07711 1/20 0.44
CTSB P07858 1/20 0.44
CTSK P43235 1/20 0.44
AGTR2 P50052 2/20 0.44
ABCB1 P08183 1/20 0.41
SPHK2 Q9NRA0 1/20 0.41
MC4R P32245 2/20 0.41
MC3R P41968 2/20 0.41
MC1R Q01726 2/20 0.41
MMP9 P14780 1/20 0.40
BCHE P06276 1/20 0.39
EPHX2 P34913 1/20 0.39
S1PR5 Q9H228 1/20 0.39
ALDH1A1 P00352 2/20 0.38
NAAA Q02083 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5048525 1.00 BDKRB2 (0.54) BDKRB2CTSLCTSBCTSKAGTR2
SCHEMBL26605025 1.00 BDKRB2 (0.54) BDKRB2CTSLCTSBCTSKAGTR2
SCHEMBL15798198 1.00 BDKRB2 (0.54) BDKRB2CTSLCTSBCTSKAGTR2
SCHEMBL1162325 0.88 BDKRB2 (0.43) BDKRB2MC4RMC3RMC1REPHX2
SCHEMBL29385583 0.85 BDKRB2 (0.51) BDKRB2CTSLCTSBCTSKAGTR2
SCHEMBL28590950 0.84 ALDH1A1 (0.41) BDKRB2SPHK2ALDH1A1
SCHEMBL71548 0.84 ABCB1 (0.58) BDKRB2ABCB1
SCHEMBL30421047 0.84 ABCB1 (0.58) BDKRB2ABCB1
SCHEMBL3855580 0.84 ABCB1 (0.58) BDKRB2ABCB1
SCHEMBL28995867 0.84 ABCB1 (0.58) BDKRB2ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2931727-A1 DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN Abbvie Inc. (US) 2015-10-21 EP disclosed
WO-2014093337-A1 DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN ABBVIE, INC. (US) 2014-06-19 WO disclosed
EP-2349244-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2011-08-03 EP disclosed
WO-2010042892-A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2010-04-15 WO disclosed
EP-1409463-B1 N-HETEROCYCLIC INHIBITORS OF TNF-ALPHA EXPRESSION BRISTOL MYERS SQUIBB CO (US) 2010-02-24 EP disclosed