Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | EIF4E | P06730 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29962438 | 0.85 | ALDH1A1 (0.59) | TDP1ALDH1A1EIF4EHSD17B10HSD11B1 | |
| SCHEMBL1558204 | 0.85 | ALDH1A1 (0.59) | TDP1ALDH1A1EIF4EHSD17B10HSD11B1 | |
| SCHEMBL14797279 | 0.81 | EIF4E (0.75) | EIF4E | |
| SCHEMBL23188582 | 0.79 | TDP1 (0.56) | TDP1ALDH1A1HSD17B10MAPTTSHR | |
| SCHEMBL19320092 | 0.79 | TDP1 (0.51) | TDP1ALDH1A1EIF4EHSD17B10HSD11B1 | |
| SCHEMBL11633060 | 0.78 | TDP1 (0.54) | TDP1ALDH1A1HSD17B10MAPTTSHR | |
| SCHEMBL15055251 | 0.76 | ALDH1A1 (0.66) | TDP1ALDH1A1HSD17B10MAPTMGAM | |
| SCHEMBL1721464 | 0.76 | ALDH1A1 (0.71) | TDP1ALDH1A1EIF4EHSD17B10HSD11B1 | |
| SCHEMBL31903101 | 0.76 | ALDH1A1 (0.71) | TDP1ALDH1A1EIF4EHSD17B10HSD11B1 | |
| SCHEMBL17420850 | 0.76 | ALDH1A1 (0.66) | TDP1ALDH1A1HSD17B10MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384760-B2 | Substituted carbazole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-12 | — | — | US | disclosed |
| CN-114829350-B | Substituted carbazole compounds | 百时美施贵宝公司 | 2024-05-28 | — | — | CN | disclosed |
| US-20240076280-A1 | SUBSTITUTED CARBAZOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2024-03-07 | — | — | US | disclosed |
| EP-4038059-B1 | SUBSTITUTED CARBAZOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-20 | — | — | EP | disclosed |
| EP-4038059-A1 | SUBSTITUTED CARBAZOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114829350-A | Substituted carbazole compounds | 百时美施贵宝公司 | 2022-07-29 | — | — | CN | disclosed |
| WO-2021067657-A1 | SUBSTITUTED CARBAZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-08 | — | — | WO | disclosed |
| WO-2021067657-A1 | SUBSTITUTED CARBAZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240076280-A1 | SUBSTITUTED CARBAZOLE COMPOUNDS | TLR7, TLR3, TLR1 | TDP1 1533/4885ALDH1A1 1776/4885EIF4E 2508/4885 |
| US-12384760-B2 | Substituted carbazole compounds | TLR7, TLR3, TLR1 | TDP1 1533/4885ALDH1A1 1776/4885EIF4E 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.