Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.54 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IL2 | P60568 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780014 | 1.00 | STIM1 (0.54) | STIM1ORAI1ORAI2MEN1KMT2A | |
| SCHEMBL1701211 | 0.90 | MEN1 (0.59) | STIM1ORAI1ORAI2MEN1KMT2A | |
| SCHEMBL16320788 | 0.84 | L3MBTL1 (0.55) | STIM1ORAI1ORAI2MEN1KMT2A | |
| SCHEMBL15216422 | 0.80 | NPC1 (0.57) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL11911928 | 0.79 | MEN1 (0.59) | STIM1ORAI1ORAI2MEN1KMT2A | |
| SCHEMBL14893401 | 0.78 | SMN1; SMN2 (0.49) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL29216896 | 0.78 | STIM1 (0.69) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL15206208 | 0.78 | NPC1 (0.70) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL15205269 | 0.78 | NPC1 (0.62) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL16381659 | 0.77 | KMT2A (0.54) | STIM1ORAI1ORAI2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12522589-B2 | Synthesis of CRAC channel inhibitors | CALCIMEDICA, INC. (US) | 2026-01-13 | — | — | US | disclosed |
| US-20240010638-A1 | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS | AVENUE CAPITAL MANAGEMENT II, L.P. | 2024-01-11 | — | — | US | disclosed |
| CN-116847837-A | Improved synthesis of CRAC channel inhibitors | 钙医学公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2022101654-A1 | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS | CALCIMEDICA, INC. (US) | 2022-05-19 | — | — | WO | disclosed |
| WO-2021057890-A1 | 2H-BENZOPYRAN DERIVATIVES AS CRAC INHIBITORS | 南京明德新药研发有限公司 | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240010638-A1 | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS | CACNA1E, CACNA1C, ORAI1 | STIM1 52/4885ORAI1 3/4885ORAI2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.