Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15832232 | 0.83 | AR (0.46) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL23176301 | 0.81 | MAPT (0.38) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL23176227 | 0.81 | MAPT (0.34) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL23176152 | 0.79 | MAPT (0.36) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL24375638 | 0.76 | RAB9A (0.42) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL15935038 | 0.73 | RAB9A (0.47) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL22040944 | 0.69 | MAPT (0.43) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL22040943 | 0.69 | RAB9A (0.43) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL24375640 | 0.68 | IRAK4 (0.43) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL22041242 | 0.67 | RAB9A (0.41) | MAPTRAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934538-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2021-03-31 | — | — | EP | disclosed |