Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 16/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 16/20 | 0.39 |
| ▸ | ITGAL | P20701 | 16/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12651397 | 0.78 | PIK3CA (0.43) | HDAC6ITGB2ICAM1ITGAL | |
| SCHEMBL18867799 | 0.77 | ITGB2 (0.55) | ITGB2ICAM1ITGAL | |
| SCHEMBL18868494 | 0.70 | ITGB2 (0.80) | ITGB2ICAM1ITGAL | |
| SCHEMBL12370119 | 0.69 | PIK3CA (0.44) | LMNA | |
| SCHEMBL10156369 | 0.67 | DRD2 (0.44) | — | |
| SCHEMBL10129657 | 0.66 | ITGB2 (0.62) | HDAC6ITGB2ICAM1ITGAL | |
| SCHEMBL18885628 | 0.66 | ITGB2 (0.59) | HDAC6ITGB2ICAM1ITGAL | |
| SCHEMBL18868550 | 0.65 | NPSR1 (0.37) | HDAC6ITGB2ICAM1ITGALHPGD | |
| SCHEMBL15445338 | 0.64 | ITGB2 (0.52) | ITGB2ICAM1ITGAL | |
| SCHEMBL13167800 | 0.63 | PIK3CA (0.47) | HDAC6ITGB2ICAM1ITGALLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797775-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETIC RETINOPATHY | Novartis AG (CH) | 2021-03-31 | — | — | EP | disclosed |