Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 7/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531700 | 0.86 | PLTP (0.55) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2315607 | 0.84 | SMN1; SMN2 (0.52) | PLTPRORCDGAT1NPC1HPGD | |
| SCHEMBL2315616 | 0.84 | PLTP (0.51) | PLTPRORCDGAT1NPC1HPGD | |
| SCHEMBL2487506 | 0.83 | PLTP (0.52) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2490496 | 0.83 | PLTP (0.52) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2484995 | 0.83 | PLTP (0.51) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2485677 | 0.83 | PLTP (0.51) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2488081 | 0.82 | PLTP (0.50) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2491014 | 0.82 | ADORA1 (0.55) | PLTPADORA2AADORA1RORCDGAT1 | |
| SCHEMBL2360230 | 0.82 | DGAT1 (0.59) | PLTPADORA2AADORA1RORCDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |