Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23182604 | 0.89 | KMT2A (0.54) | KMT2AATMNPC1MEN1SMN1; SMN2 | |
| SCHEMBL23182505 | 0.88 | MEN1 (0.51) | KMT2ANPC1TSHRRAB9AMEN1 | |
| SCHEMBL23182908 | 0.76 | KDM4E (0.54) | KMT2AMEN1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL22956490 | 0.76 | HPGD (0.40) | KMT2ANPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL23383741 | 0.76 | ATF4 (0.46) | KMT2AATMRAB9AMEN1SMN1; SMN2 | |
| SCHEMBL25962494 | 0.75 | KDM4E (0.53) | KMT2ARAB9AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL23383747 | 0.74 | CYP1A2 (0.49) | KMT2ARAB9AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL23182495 | 0.73 | TDP1 (0.54) | KMT2ANPC1MEN1SMN1; SMN2TDP1 | |
| SCHEMBL23383744 | 0.73 | HTT (0.57) | KMT2ARAB9AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL25808564 | 0.73 | TDP1 (0.52) | KMT2ANPC1TSHRRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | ATF4, ATF1, XBP1 | KMT2A 2770/4885ATM 1977/4885NPC1 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.