Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627742 | 0.94 | TDP1 (0.51) | TDP1EPHX2MEN1KMT2ANPC1 | |
| SCHEMBL22627852 | 0.90 | TRPV1 (0.43) | TDP1EPHX2KMT2A | |
| SCHEMBL22627589 | 0.89 | TDP1 (0.39) | TDP1EPHX2MEN1KMT2ACYP2C9 | |
| SCHEMBL22627559 | 0.88 | ATF4 (0.41) | TDP1EPHX2 | |
| SCHEMBL25804643 | 0.86 | RXFP1 (0.51) | TDP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL23182495 | 0.84 | TDP1 (0.54) | TDP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL25812812 | 0.82 | TRPV1 (0.45) | TDP1EPHX2 | |
| SCHEMBL23182505 | 0.80 | MEN1 (0.51) | TDP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL23384171 | 0.78 | MEN1 (0.48) | TDP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL23182908 | 0.78 | KDM4E (0.54) | TDP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |