Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631568 | 0.83 | ATF4 (0.52) | ATF4LMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL25962524 | 0.81 | ATF4 (0.50) | ATF4ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL20631381 | 0.79 | ATF4 (0.48) | ATF4ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL20631576 | 0.77 | ATF4 (0.56) | ATF4LMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL20632011 | 0.76 | TSHR (0.45) | ATF4ALDH1A1NPSR1NPC1TSHR | |
| SCHEMBL17658584 | 0.75 | ATF4 (0.76) | ATF4LMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL22777409 | 0.72 | ATF4 (0.70) | ATF4LMNAALDH1A1KMT2ANPC1 | |
| SCHEMBL17656879 | 0.72 | ATF4 (0.70) | ATF4LMNAALDH1A1KMT2ANPC1 | |
| SCHEMBL16082980 | 0.72 | ATF4 (1.00) | ATF4LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL16083047 | 0.72 | ATF4 (1.00) | ATF4LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | ATF4, ATF1, XBP1 | ATF4 1/4885LMNA 3667/4885ALDH1A1 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.