Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATF4 | P18848 | 6/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631270 | 0.80 | ALDH1A1 (0.50) | TSHRNPC1RAB9AATF4CHRM1 | |
| SCHEMBL25962524 | 0.78 | ATF4 (0.50) | TSHRNPC1RAB9AATF4ALDH1A1 | |
| SCHEMBL20610422 | 0.77 | ATF4 (0.69) | TSHRNPC1RAB9AATF4KDM4E | |
| SCHEMBL20631568 | 0.77 | ATF4 (0.52) | TSHRNPC1RAB9AATF4ALDH1A1 | |
| SCHEMBL23182883 | 0.76 | ATF4 (0.55) | TSHRNPC1RAB9AATF4ALDH1A1 | |
| SCHEMBL20631259 | 0.75 | ALDH1A1 (0.47) | TSHRNPC1RAB9AATF4ALDH1A1 | |
| SCHEMBL23383738 | 0.72 | KDM4E (0.51) | ATF4SMN1; SMN2KDM4E | |
| SCHEMBL20631576 | 0.72 | ATF4 (0.56) | TSHRNPC1RAB9AATF4SMN1; SMN2 | |
| SCHEMBL20631381 | 0.72 | ATF4 (0.48) | ATF4SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL20632026 | 0.68 | KMT2A (0.44) | TSHRNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008506-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-10 | — | — | WO | disclosed |