Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20351047 | 0.80 | KDM4E (0.48) | JAK2JAK1TYK2JAK3HSD11B1 | |
| SCHEMBL23183456 | 0.75 | JAK2 (0.40) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL23183409 | 0.66 | ALDH1A1 (0.41) | ALDH1A1TSHRLMNAHTTTP53 | |
| SCHEMBL20350859 | 0.66 | ALDH1A1 (0.51) | ALDH1A1TSHRLMNAHTTTP53 | |
| SCHEMBL23183455 | 0.64 | ATM (0.54) | ALDH1A1TSHRLMNAHTTHSD17B10 | |
| SCHEMBL20351058 | 0.63 | ALDH1A1 (0.48) | ALDH1A1TSHRLMNAHTTTP53 | |
| SCHEMBL10654782 | 0.62 | KDM6B (0.46) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL4896857 | 0.61 | ALDH1A1 (0.52) | ALDH1A1TSHRLMNAHTTTP53 | |
| SCHEMBL20339831 | 0.61 | KDM4E (0.51) | JAK2JAK1TYK2JAK3ALDH1A1 | |
| SCHEMBL23183523 | 0.60 | KDM4E (0.58) | ALDH1A1TSHRLMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ORSOBIO, INC. | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ALDH7A1, OTC, DDC | JAK2 3351/4885JAK1 3692/4885TYK2 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.