Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3484898 | 0.85 | EPHX2 (0.49) | EPHX2MAPK10GAAALDH1A1BRD4 | |
| SCHEMBL3484895 | 0.85 | EPHX2 (0.49) | EPHX2MAPK10GAAALDH1A1BRD4 | |
| SCHEMBL9025120 | 0.75 | EPHX2 (0.40) | EPHX2MAPK10GAAIDO1KMT2A | |
| SCHEMBL21156327 | 0.74 | EPHX2 (0.46) | EPHX2MAPK10GAAALDH1A1BRD4 | |
| SCHEMBL29270785 | 0.72 | GAA (0.43) | EPHX2GAAALDH1A1NFKB1NFKB2 | |
| SCHEMBL29270803 | 0.71 | GAA (0.43) | EPHX2GAANFKB1NFKB2RELA | |
| SCHEMBL30675690 | 0.71 | GAA (0.43) | EPHX2GAABRD4CREBBPNFKB1 | |
| SCHEMBL25766504 | 0.71 | GAA (0.43) | EPHX2GAABRD4CREBBPNFKB1 | |
| SCHEMBL29270789 | 0.71 | GAA (0.43) | EPHX2GAABRD4CREBBPNFKB1 | |
| SCHEMBL12569080 | 0.70 | RIPK1 (0.52) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-04-07 | — | — | EP | disclosed |