Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 15/20 | 0.54 |
| ▸ | HTR1A | P08908 | 8/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231889 | 1.00 | HTR7 (0.54) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL9280103 | 0.86 | POLB (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL14199082 | 0.81 | HTR7 (0.51) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL30215698 | 0.80 | HTR7 (0.50) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL185755 | 0.80 | HTR7 (0.50) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL4656369 | 0.75 | HTR7 (0.57) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL6696116 | 0.75 | HTR7 (0.57) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL5394439 | 0.74 | HTR7 (0.53) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL5113192 | 0.74 | HTR7 (0.53) | HTR7HTR1APRMT5WDR77DRD2 | |
| SCHEMBL2954869 | 0.74 | HTR7 (0.53) | HTR7HTR1APRMT5WDR77DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840915-A | REACTING RACEMIC OXINDOLE WITH CHLOROACETONITRILE IN MIXTURE CONTAINING CATALYST AND SODIUM HYDROXIDE AS DEPROTONATING AGENT, RECRYSATLLIZING, REDUCING NITRILE GROUPS, CONTACTING WITH CHIRAL ACID TO PRECIPITATE SALT | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-24 | — | — | US | claimed |
| US-8362067-B2 | 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-01-29 | — | — | US | disclosed |
| US-8362067-B2 | 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-01-29 | — | — | US | disclosed |
| US-8362067-B2 | 3-aminoalkyl-1,3-dihydro-2H-indol-2-one derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-01-29 | — | — | US | disclosed |
| EP-2265582-B1 | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF. | SANOFI SA (FR) | 2012-01-04 | — | — | EP | disclosed |
| CN-102015642-A | Novel 3-aminoalkyl-1, 3-dihydro-2H-indol-2-one derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS | 2011-04-13 | — | — | CN | disclosed |
| US-20110059955-A1 | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-10 | — | — | US | disclosed |
| US-20110059955-A1 | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059955-A1 | NOVEL 3-AMINOALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | AVPR1B, AVPR1A, AVPR2 | HTR7 163/4885HTR1A 57/4885PRMT5 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.