SCHEMBL23190959

SCHEMBL23190959

C=C(CC)C(=O)c1ccc(C=O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
ALDH3A1 P30838 1/20 0.41
ALDH1A3 P47895 1/20 0.41
EGFR P00533 2/20 0.40
PARP10 Q53GL7 1/20 0.40
PARP3 Q9Y6F1 1/20 0.40
CYP2A6 P11509 3/20 0.39
ALDH5A1 P51649 1/20 0.39
ABAT P80404 1/20 0.39
EPHX2 P34913 1/20 0.39
NR1H4 Q96RI1 1/20 0.39
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
HTT P42858 2/20 0.37
USP2 O75604 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5694688 0.80 ESR1 (0.56) MAPK1THRBTYRKDM4E
SCHEMBL5694685 0.80 ESR1 (0.56) MAPK1THRBTYRKDM4E
SCHEMBL3757660 0.77 ALDH1A1 (0.68) ALDH1A1EGFRPARP10PARP3CYP2A6
SCHEMBL6577194 0.76 ALDH1A1 (0.56) ALDH1A1ALDH3A1ALDH1A3PARP10PARP3
SCHEMBL5807628 0.76 EGFR (0.63) ALDH1A1EGFRCES2CES1HTT
SCHEMBL12344141 0.75 ALDH1A1 (0.54) ALDH1A1EGFRPARP10PARP3CYP2A6
SCHEMBL27891771 0.74 KMT2A (0.51) ALDH1A1ALDH3A1ALDH1A3PARP10PARP3
Propionic Acid SCHEMBL28665177 0.73 ALDH1A1 (0.76) ALDH1A1ALDH3A1ALDH1A3PARP10PARP3
SCHEMBL29017437 0.73 ALDH1A1 (0.50) ALDH1A1ALDH3A1ALDH1A3PARP10PARP3
SCHEMBL27583157 0.71 ALDH1A1 (0.46) ALDH1A1ALDH3A1ALDH1A3PARP10PARP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218009-B1 PROCESS FOR THE CONJUGATION OF A PEPTIDE OR PROTEIN WITH A REAGENT COMPRISING A LEAVING GROUP INCLUDING A PORTION OF PEG POLYTHERICS LTD (GB) 2021-04-07 EP disclosed