Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433508 | 1.00 | KMT2A (0.36) | KMT2ANPC1POLBRAB9ASLC2A1 | |
| SCHEMBL2320224 | 0.95 | KMT2A (0.37) | KMT2ANPC1POLBRAB9ASLC2A1 | |
| SCHEMBL12432836 | 0.95 | KMT2A (0.37) | KMT2ANPC1POLBRAB9ASLC2A1 | |
| SCHEMBL2321347 | 0.92 | DRD2 (0.41) | KMT2ANPC1POLBRAB9ADRD3 | |
| SCHEMBL12433054 | 0.92 | DRD2 (0.41) | KMT2ANPC1POLBRAB9ADRD3 | |
| SCHEMBL2318094 | 0.90 | CCNE1 (0.37) | GSK3BCCNE1CDK2ACKR3 | |
| SCHEMBL2316242 | 0.90 | DRD4 (0.39) | KMT2ANPC1POLBRAB9ADRD3 | |
| SCHEMBL12432710 | 0.90 | DRD4 (0.39) | KMT2ANPC1POLBRAB9ADRD3 | |
| SCHEMBL2315624 | 0.88 | KMT2A (0.40) | KMT2ANPC1POLBRAB9ADRD3 | |
| SCHEMBL12433056 | 0.88 | KMT2A (0.40) | KMT2ANPC1POLBRAB9ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125782-B1 | ARYL CARBOXYLIC ACID CYCLOHEXYL AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-08-03 | — | — | EP | claimed |
| EP-2125782-B1 | ARYL CARBOXYLIC ACID CYCLOHEXYL AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2008101905-A1 | ARYL CARBOXYLIC ACID CYCLOHEXYL AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2008-08-28 | — | — | WO | disclosed |