Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433054 | 1.00 | DRD2 (0.41) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL12432710 | 0.94 | DRD4 (0.39) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL2316242 | 0.94 | DRD4 (0.39) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL12433508 | 0.92 | KMT2A (0.36) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL2319213 | 0.92 | KMT2A (0.36) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL12433056 | 0.90 | KMT2A (0.40) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL2315624 | 0.90 | KMT2A (0.40) | DRD2DRD3NPC1POLBRAB9A | |
| SCHEMBL2318163 | 0.90 | DRD2 (0.36) | DRD2DRD3KMT2ADRD4SMN1; SMN2 | |
| SCHEMBL2316735 | 0.88 | MAOB (0.38) | DRD2DRD3POLBKMT2AHTR1A | |
| SCHEMBL14134841 | 0.88 | MAOB (0.38) | DRD2DRD3POLBKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125782-B1 | ARYL CARBOXYLIC ACID CYCLOHEXYL AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-08-03 | — | — | EP | claimed |
| EP-2125782-B1 | ARYL CARBOXYLIC ACID CYCLOHEXYL AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-08-03 | — | — | EP | disclosed |