Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 18/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23201032 | 1.00 | STING1 (0.44) | STING1NPC1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL21643845 | 0.84 | STING1 (0.42) | STING1CYP3A4 | |
| SCHEMBL21643841 | 0.84 | STING1 (0.42) | STING1CYP3A4 | |
| SCHEMBL21643887 | 0.84 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL19437550 | 0.76 | TLR8 (0.52) | STING1NPC1 | |
| SCHEMBL22121411 | 0.74 | KMT2A (0.52) | — | |
| SCHEMBL23077417 | 0.74 | STING1 (0.53) | STING1 | |
| SCHEMBL23077419 | 0.74 | STING1 (0.53) | STING1 | |
| SCHEMBL22121231 | 0.74 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL22121522 | 0.73 | STING1 (0.65) | STING1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802534-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS STING ACTIVATORS | Incyte Corporation (US) | 2021-04-14 | — | — | EP | disclosed |