Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 17/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22925517 | 0.89 | STING1 (0.65) | STING1CYP3A4 | |
| SCHEMBL22121522 | 0.89 | STING1 (0.65) | STING1CYP3A4 | |
| SCHEMBL21643845 | 0.87 | STING1 (0.42) | STING1CYP3A4 | |
| SCHEMBL21643841 | 0.87 | STING1 (0.42) | STING1CYP3A4 | |
| SCHEMBL23095398 | 0.86 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL29437070 | 0.86 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL22121231 | 0.85 | STING1 (0.54) | STING1CYP3A4 | |
| SCHEMBL23201034 | 0.84 | STING1 (0.44) | STING1CYP3A4 | |
| SCHEMBL23201032 | 0.84 | STING1 (0.44) | STING1CYP3A4 | |
| SCHEMBL23077541 | 0.84 | STING1 (0.57) | STING1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2023-08-01 | — | — | US | disclosed |
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | INCYTE CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | INCYTE CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-11427597-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2022-08-30 | — | — | US | disclosed |
| EP-3802534-B1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS STING ACTIVATORS | INCYTE CORP (US) | 2022-07-13 | — | — | EP | disclosed |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | INCYTE CORPORATION (US) | 2021-03-16 | — | — | US | disclosed |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | INCYTE CORPORATION (US) | 2020-12-29 | — | — | US | disclosed |
| WO-2020132566-A1 | STING PYRAZOLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132582-A1 | STING AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020028566-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION (US) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020028566-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION (US) | 2020-02-06 | — | — | WO | disclosed |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION | 2020-02-06 | — | — | US | disclosed |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | INCYTE CORPORATION | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11596692-B1 | PD-L1/STING conjugates and methods of use | STING1, PDCD1LG2, CD274 | STING1 1/4885CYP3A4 4862/4885BRD4 636/4885 |
| US-20230398225-A1 | PD-L1/STING CONJUGATES AND METHODS OF USE | STING1, PDCD1LG2, CD274 | STING1 1/4885CYP3A4 4862/4885BRD4 636/4885 |
| US-11713317-B2 | Tricyclic heterocyclic compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 2421/4885BRD4 398/4885 |
| US-10875872-B2 | Heteroaryl amide compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 3653/4885BRD4 286/4885 |
| US-10947227-B2 | Tricyclic heterocyclic compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 2421/4885BRD4 398/4885 |
| US-11427597-B2 | Heteroaryl amide compounds as sting activators | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 3653/4885BRD4 286/4885 |
| US-20200039994-A1 | HETEROARYL AMIDE COMPOUNDS AS STING ACTIVATORS | STING1, MAVS, IRF3 | STING1 1/4885CYP3A4 3653/4885BRD4 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.