Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463762 | 1.00 | ACE (0.57) | ACECTSKSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23201281 | 1.00 | ACE (0.57) | ACECTSKSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4907367 | 0.87 | CTSK (0.57) | ACECTSKCAPN1CTSLCTSB | |
| SCHEMBL10045695 | 0.87 | ACE (0.55) | ACECTSKSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14341582 | 0.83 | CNR1 (0.52) | ACECTSKSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24862949 | 0.82 | CAPN1 (0.59) | ACECTSKSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2369340 | 0.82 | CAPN1 (0.61) | ACECAPN1CTSB | |
| SCHEMBL3292711 | 0.82 | CAPN1 (0.61) | ACECAPN1CTSB | |
| SCHEMBL17865652 | 0.82 | CAPN1 (0.61) | ACECAPN1CTSB | |
| SCHEMBL7732224 | 0.82 | CTSK (0.63) | CTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802489-A2 | MASP-2 INHIBITORS AND METHODS OF USE | Omeros Corporation (US) | 2021-04-14 | — | — | EP | disclosed |