Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.50 |
| ▸ | CCR8 | P51685 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31096506 | 1.00 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL13656469 | 0.79 | PTGS2 (0.47) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL5237083 | 0.78 | ADORA2A (0.48) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL23479887 | 0.76 | MET (0.43) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL23202538 | 0.76 | KDM4E (0.44) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL23202505 | 0.76 | HSD17B10 (0.48) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL11142730 | 0.76 | KMT2A (0.53) | KDM4EHTTSMN1; SMN2RAB9APKM | |
| SCHEMBL23202350 | 0.76 | KDM4E (0.42) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL23202506 | 0.76 | KDM4E (0.42) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL7283295 | 0.75 | KDM4E (0.45) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4685140-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2026-01-28 | — | — | EP | disclosed |
| EP-3801528-B1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2025-08-06 | — | — | EP | disclosed |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2025-04-29 | — | — | US | disclosed |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-27 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
| EP-3801528-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2021-04-14 | — | — | EP | disclosed |
| CN-112533601-A | EAAT2 activators and methods of use thereof | 俄亥俄州创新基金会 | 2021-03-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702403-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885LMNA 3566/4885CCR1 4655/4885 |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885LMNA 3566/4885CCR1 4655/4885 |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885LMNA 3566/4885CCR1 4655/4885 |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885LMNA 3566/4885CCR1 4655/4885 |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885LMNA 3566/4885CCR1 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.