Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21456184 | 0.83 | OPRM1 (0.46) | OPRM1OPRD1OPRK1HTR2AADRA2A | |
| SCHEMBL21405486 | 0.80 | GPR119 (0.44) | IRAK4 | |
| SCHEMBL21456389 | 0.74 | OPRM1 (0.51) | OPRM1OPRD1OPRK1HTR2AADRA2A | |
| SCHEMBL20012788 | 0.74 | OPRM1 (0.51) | OPRM1OPRD1OPRK1SMARCA2SMARCA4 | |
| SCHEMBL21405035 | 0.73 | OPRM1 (0.41) | OPRM1HTR2AHTR2CHTR2BROCK2 | |
| SCHEMBL21421850 | 0.71 | GPR119 (0.40) | — | |
| SCHEMBL6963244 | 0.70 | HRH4 (0.46) | CXCR4 | |
| SCHEMBL23205589 | 0.68 | OPRM1 (0.45) | OPRM1SMARCA2SMARCA4 | |
| SCHEMBL8565055 | 0.66 | UHRF1 (0.43) | ADRA1A | |
| SCHEMBL22802680 | 0.66 | KCNH2 (0.41) | OPRM1HTR2AKCNH2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021067606-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |