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SCHEMBL23205486

SCHEMBL23205486

CC(C)(C)OC(=O)N1CCC(C(=O)N2CCC(O[C@H]3C[C@H](Oc4cc(Br)ccn4)C3)CC2)CC1

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 16/20 0.51
▸ HPGD P15428 1/20 0.46
▸ RECQL P46063 1/20 0.44
▸ FNTA P49354 1/20 0.42
▸ FNTB P49356 1/20 0.42
▸ PTPN2 P17706 1/20 0.39
▸ PTPN1 P18031 1/20 0.39
▸ PTPN6 P29350 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21644754 1.00 GPR119 (0.51) GPR119HPGDRECQLFNTAFNTB
SCHEMBL21405347 0.94 GPR119 (0.53) GPR119
SCHEMBL21456063 0.94 GPR119 (0.53) GPR119
SCHEMBL23205355 0.94 GPR119 (0.53) GPR119
SCHEMBL21673925 0.89 GPR119 (0.47) GPR119
SCHEMBL21644749 0.89 GPR119 (0.47) GPR119
SCHEMBL22156950 0.86 GPR119 (0.53) GPR119
SCHEMBL25278138 0.85 GPR119 (0.45) GPR119
SCHEMBL25626363 0.85 GPR119 (0.45) GPR119
SCHEMBL20120962 0.82 GPR119 (0.64) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023097031-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2023-06-01 — — WO disclosed
WO-2021067606-A1 BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2021-04-08 — — WO disclosed