Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31092717 | 0.89 | MAPT (0.44) | MAPTGAANAMPTSIRT3TDP1 | |
| SCHEMBL17541892 | 0.84 | SMYD3 (0.39) | MAPTGAANAMPTSIRT3TDP1 | |
| Hydrochloric Acid SCHEMBL21545777 | 0.83 | SMYD3 (0.39) | NAMPTSIRT3TDP1NNMTCHRNB2 | |
| SCHEMBL13660486 | 0.79 | NAMPT (0.42) | MAPTGAANAMPTHRH4TSHR | |
| SCHEMBL10742930 | 0.76 | GAA (0.71) | MAPTGAA | |
| SCHEMBL30900484 | 0.76 | GAA (0.71) | MAPTGAA | |
| SCHEMBL2266601 | 0.76 | GAA (0.71) | MAPTGAA | |
| Hydrochloric Acid SCHEMBL28262901 | 0.75 | GAA (0.69) | MAPTGAA | |
| SCHEMBL22411406 | 0.73 | MAPT (0.41) | MAPTGAANAMPTCHRNB2CHRNA4 | |
| SCHEMBL13271647 | 0.72 | CHRNB2 (0.35) | MAPTGAANNMTSIRT6CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021068755-A1 | COMPOUND HAVING BRD4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2021-04-15 | — | — | WO | disclosed |