Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 7/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23213891 | 0.96 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29619684 | 0.96 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213887 | 0.96 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213543 | 0.91 | CHRM4 (0.48) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29619696 | 0.89 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213411 | 0.89 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213409 | 0.89 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213165 | 0.87 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23213162 | 0.87 | CHRM4 (0.50) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23230168 | 0.85 | CHRM4 (0.40) | CHRM4CHRM1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021070091-A1 | 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS AG (CH) | 2021-04-15 | — | — | WO | disclosed |