Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18576516 | 0.86 | KDM4E (0.62) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL29845235 | 0.83 | HSD17B10 (0.60) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL23213705 | 0.83 | HSD17B10 (0.60) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL30071406 | 0.82 | LMNA (0.47) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL15622512 | 0.79 | KDM4E (0.67) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL18562157 | 0.78 | KDM4E (0.65) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL15631853 | 0.77 | KMT2A (1.00) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL17322837 | 0.75 | KDM4E (0.69) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL15631877 | 0.75 | KDM4E (0.81) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL17322840 | 0.75 | KDM4E (0.69) | KDM4ESMN1; SMN2KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041729-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2023-09-27 | — | — | EP | disclosed |
| US-20220370451-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2022-11-24 | — | — | US | disclosed |
| EP-4041729-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021070054-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220370451-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | EIF2AK2, SAMHD1, POLR2H | KDM4E 2356/4885SMN1; SMN2 2727/4885KMT2A 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.