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Taltirelin

Taltirelin

SCHEMBL2321397

CN1C(=O)C[C@@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(N)=O)NC1=O.NCCCCC(N)C(=O)O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TRHR

The experimentally established mechanism targets of Taltirelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ TRHR known ✓ P34981 3/20 0.61
▸ REN P00797 10/20 0.46
▸ APLNR P35414 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Taltirelin SCHEMBL13993039 0.90 TRHR (0.73) TRHR
Taltirelin SCHEMBL194528 0.90 TRHR (0.73) TRHR
Taltirelin SCHEMBL2320945 0.90 TRHR (0.69) TRHRREN
Taltirelin SCHEMBL2289290 0.90 TRHR (0.72) TRHR
Taltirelin SCHEMBL30892167 0.90 TRHR (0.72) TRHR
Azetirelin SCHEMBL195158 0.82 TRHR (0.85) TRHR
Taltirelin SCHEMBL22077031 0.78 TRHR (0.65) TRHRREN
Protirelin SCHEMBL4406163 0.77 TRHR (0.93) TRHR
Taltirelin SCHEMBL21219549 0.77 TRHR (0.57) TRHR
Taltirelin SCHEMBL21219551 0.77 TRHR (0.57) TRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3362071-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY Grünenthal GmbH (DE) 2018-08-22 — — EP disclosed
WO-2017049294-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2017-03-23 — — WO disclosed
WO-2011097269-A9 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2012-12-27 — — WO disclosed
EP-2531200-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY Thar Pharmaceuticals, Inc. (US) 2012-12-12 — — EP disclosed
WO-2011097269-A1 CRYSTALLIZATION METHOD AND BIOAVAILABILITY THAR PHARMACEUTICALS, INC. (US) 2011-08-11 — — WO disclosed