Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.85 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.85 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.85 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.85 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.87 |
| ▸ | MAPT | P10636 | 3/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.87 |
| ▸ | TP53 | P04637 | 2/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.87 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | GMNN | O75496 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | STAT6 | P42226 | 1/20 | 0.87 |
| ▸ | RAD52 | P43351 | 1/20 | 0.87 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.87 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioridazine SCHEMBL30827481 | 0.93 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL8006297 | 0.93 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL29387384 | 0.93 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL41430 | 0.93 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL56533 | 0.93 | PIM1 (0.96) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL2577719 | 0.92 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL29384252 | 0.92 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL12434241 | 0.92 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL9566 | 0.92 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL380206 | 0.92 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230392065-A1 | MONOVALENT BRINE-BASED RESERVOIR DRILLING FLUID | SCHLUMBERGER TECHNOLOGY CORP (US) | 2023-12-07 | — | — | US | disclosed |
| US-11767457-B2 | Monovalent brine-based reservoir drilling fluid | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2023-09-26 | — | — | US | disclosed |
| US-20180201820-A1 | Monovalent Brine-Based Reservoir Drilling Fluid | SCHLUMBERGER TECHNOLOGY CORPORATION | 2018-07-19 | — | — | US | disclosed |
| US-20170088763-A1 | INTERNAL BREAKER COMPOSITIONS FOR WELLBORE APPLICATIONS | M-I L.L.C. (US) | 2017-03-30 | — | — | US | disclosed |
| WO-2017007978-A1 | MONOVALENT BRINE-BASED RESERVOIR DRILLING FLUID | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2017-01-12 | — | — | WO | disclosed |
| US-20160152882-A1 | CATALYTIC SYSTEM FOR BREAKER FLUID FORMULATIONS | MI LLC (US) | 2016-06-02 | — | — | US | disclosed |
| US-20160068736-A1 | REVERSIBLE FOAMED WELLBORE FLUIDS | M-I L.L.C. | 2016-03-10 | — | — | US | disclosed |
| US-20150175871-A1 | BREAKER FLUID | M-I, L.L.C. (US) | 2015-06-25 | — | — | US | disclosed |
| US-8881822-B2 | Non-aqueous breaker fluids and methods of use thereof | M-1 L.L.C. (US) | 2014-11-11 | — | — | US | disclosed |
| WO-2014172399-A1 | REVERSIBLE FOAMED WELLBORE FLUIDS | M-I L.L.C. (US) | 2014-10-23 | — | — | WO | disclosed |
| WO-2014163947-A1 | PROTECTIVE COLLOID STABILIZED FLUIDS | M-I DRILLING FLUIDS U.K. LIMITED (GB) | 2014-10-09 | — | — | WO | disclosed |
| US-20140151042-A1 | Chelate Compositions And Methods And Fluids For Use In Oilfield Operations | M-I L.L.C. (US) | 2014-06-05 | — | — | US | disclosed |
| WO-2014011587-A1 | BREAKER FLUID | M-I L.L.C. (US) | 2014-01-16 | — | — | WO | disclosed |
| WO-2012116032-A1 | CHELATE COMPOSITIONS AND METHODS AND FLUIDS FOR USE IN OILFIELD OPERATIONS | M-I L.L.C. (US) | 2012-08-30 | — | — | WO | disclosed |
| US-20110214874-A1 | NON-AQUEOUS BREAKER FLUIDS AND METHODS OF USE THEREOF | M-I L.L.C. (US) | 2011-09-08 | — | — | US | disclosed |
| EP-2352898-A2 | NON-AQUEOUS BREAKER FLUIDS AND METHODS OF USE THEREOF | M-I LLC (US) | 2011-08-10 | — | — | EP | disclosed |
| US-20110053811-A1 | METHODS FOR PREVENTING OR REMEDIATING XANTHAN DEPOSITION | M-I L.L.C. (US) | 2011-03-03 | — | — | US | disclosed |
| EP-2245107-A2 | METHODS FOR PREVENTING OR REMEDIATING XANTHAN DEPOSITION | M.I L.L, C. (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010053904-A2 | NON-AQUEOUS BREAKER FLUIDS AND METHODS OF USE THEREOF | M-I L.L.C. (US) | 2010-05-14 | — | — | WO | disclosed |
| WO-2009091652-A2 | METHODS FOR PREVENTING OR REMEDIATING XANTHAN DEPOSITION | M-I L.L.C. (US) | 2009-07-23 | — | — | WO | disclosed |