Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.98 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.98 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | STAT6 | P42226 | 1/20 | 1.00 |
| ▸ | RAD52 | P43351 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioridazine SCHEMBL41430 | 1.00 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL8006297 | 1.00 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL29387384 | 1.00 | TDP1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL380206 | 0.99 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL9566 | 0.99 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL29384252 | 0.99 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL2577719 | 0.99 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL12434241 | 0.99 | PIM1 (1.00) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL56533 | 0.97 | PIM1 (0.96) | TDP1MAPTALDH1A1TP53CYP3A4 | |
| Thioridazine SCHEMBL2321422 | 0.93 | TDP1 (0.87) | TDP1MAPTALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3785718-B1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF FLAVIVIRUS INFECTIOUS DISEASE | LEMONEX INC (KR) | 2024-03-27 | — | — | EP | claimed |