Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.96 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.96 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.96 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.96 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.96 |
| ▸ | PIM1 | P11309 | 5/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.96 |
| ▸ | HTR1A | P08908 | 4/20 | 0.96 |
| ▸ | DRD1 | P21728 | 4/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.96 |
| ▸ | MAPT | P10636 | 3/20 | 0.96 |
| ▸ | HTR7 | P34969 | 3/20 | 0.96 |
| ▸ | HTR6 | P50406 | 3/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.96 |
| ▸ | TP53 | P04637 | 2/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioridazine SCHEMBL29384252 | 0.98 | PIM1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL2577719 | 0.98 | PIM1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL380206 | 0.98 | PIM1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL9566 | 0.98 | PIM1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL12434241 | 0.98 | PIM1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL29387384 | 0.97 | TDP1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL41430 | 0.97 | TDP1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL8006297 | 0.97 | TDP1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL30827481 | 0.97 | TDP1 (1.00) | PIM1CYP2D6DRD2CYP1A2HTR1A | |
| Thioridazine SCHEMBL2321422 | 0.93 | TDP1 (0.87) | PIM1CYP2D6DRD2CYP1A2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5743 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994202-A1 | NOVEL HYDROGELS | Leibniz-Institut für Neue Materialien gemeinnützige GmbH (DE) | 2022-05-11 | — | — | EP | claimed |
| US-20220050117-A1 | GLX-DERIVED MOLECULE DETECTION | GLX ANALYTIX APS (DK) | 2022-02-17 | — | — | US | claimed |
| EP-3773600-A1 | METHODS AND COMPOSITIONS FOR TREATING HALLUCINATIONS AND CONDITIONS RELATED TO THE SAME | Enterin, Inc. (US) | 2021-02-17 | — | — | EP | claimed |
| WO-2021001203-A1 | NOVEL HYDROGELS | LEIBNIZ-INSTITUT FÜR NEUE MATERIALIEN GEMEINNÜTZIGE GMBH (DE) | 2021-01-07 | — | — | WO | claimed |
| CN-111683957-A | Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biomolecules | 埃克斯特雷莫凯姆有限公司 | 2020-09-18 | — | — | CN | claimed |
| EP-3137559-B1 | SOLID COLORANT FOR TINTING PAINT | CHROMAFLO TECH EUROPE B V (NL) | 2020-07-22 | — | — | EP | claimed |
| US-20200155574-A1 | AMINOSTEROL COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATING SCHIZOPHRENIA | ENTERIN, INC. (US) | 2020-05-21 | — | — | US | claimed |
| EP-3651762-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2020-05-20 | — | — | EP | claimed |
| WO-2019190950-A1 | METHODS AND COMPOSITIONS FOR TREATING HALLUCINATIONS AND CONDITIONS RELATED TO THE SAME | ENTERIN, INC. (US) | 2019-10-03 | — | — | WO | claimed |
| US-20190298740-A1 | METHODS AND COMPOSITIONS FOR TREATING HALLUCINATIONS AND CONDITIONS RELATED TO THE SAME | ENTERIN, INC. (US) | 2019-10-03 | — | — | US | claimed |
| WO-2000047582-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-08-17 | — | — | WO | claimed |
| EP-1000998-A1 | Electroluminescent element and devices | TORAY INDUSTRIES, INC. (JP) | 2000-05-17 | — | — | EP | claimed |
| WO-1999025353-A1 | THERAPEUTIC USES OF TRIAZOLO-PYRIDAZINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1999-05-27 | — | — | WO | claimed |
| US-5663042-A | LIGHT AND HEAT SENSITIVE SILVER HALIDE ELEMENNTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-09-02 | — | — | US | claimed |
| EP-0681210-A1 | Novel developing agents for (photo) thermographic systems | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-11-08 | — | — | EP | claimed |
| EP-0500650-B1 | PROCESS FOR PRODUCING A GEL-FREE COAGULATED RUBBER WITH LOW ETHYLENIC UNSATURATION | OLIN CORP (US) | 1995-08-09 | — | — | EP | claimed |
| EP-0500650-A4 | PROCESS FOR PRODUCING A GEL-FREE COAGULATED RUBBER WITH LOW ETHYLENIC UNSATURATION | — | 1992-11-25 | — | — | EP | claimed |
| EP-0500650-A1 | PROCESS FOR PRODUCING A GEL-FREE COAGULATED RUBBER WITH LOW ETHYLENIC UNSATURATION. | OLIN CORP (US) | 1992-09-02 | — | — | EP | claimed |
| US-5057601-A | PROCESS FOR PRODUCING A GEL-FREE COAGULATED RUBBER WITH LOW ETHYLENIC UNSATURATION | OLIN CORPORATION (US) | 1991-10-15 | — | — | US | claimed |
| WO-1991006579-A1 | PROCESS FOR PRODUCING A GEL-FREE COAGULATED RUBBER WITH LOW ETHYLENIC UNSATURATION | OLIN CORPORATION (US) | 1991-05-16 | — | — | WO | claimed |