SCHEMBL23215738

SCHEMBL23215738

COc1ccc(C(OC[C@H]2O[C@H](n3c(=O)cc[nH]c3=O)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TYMP P19971 6/20 0.50
TYMS P04818 3/20 0.42
DUT P33316 2/20 0.37
SLC6A1 P30531 2/20 0.37
SLC6A11 P48066 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27041197 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL23215194 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL31556078 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL31556063 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL23215575 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL30274838 1.00 TYMP (0.50) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL26647625 0.92 TYMP (0.47) TYMPTYMSSLC6A1SLC6A11
SCHEMBL26647627 0.92 TYMP (0.47) TYMPTYMSSLC6A1SLC6A11
SCHEMBL30274718 0.91 TYMP (0.49) TYMPTYMSDUTSLC6A1SLC6A11
SCHEMBL30274892 0.91 TYMP (0.49) TYMPTYMSDUTSLC6A1SLC6A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO WAVE LIFE SCIENCES LTD (SG) 2025-08-21 US disclosed
WO-2025072862-A9 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2025-06-26 WO disclosed
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2025-05-01 US disclosed
WO-2025072862-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2025-04-03 WO disclosed
EP-4507700-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO Wave Life Sciences Ltd. (SG) 2025-02-19 EP disclosed
US-20240026358-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2024-01-25 US disclosed
US-20230392137-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-12-07 US disclosed
WO-2023201095-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO WAVE LIFE SCIENCES LTD. (SG) 2023-10-19 WO disclosed
EP-4240849-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF Wave Life Sciences Ltd. (SG) 2023-09-13 EP disclosed
US-20230220384-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-07-13 US disclosed
EP-4022059-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF Wave Life Sciences Ltd. (SG) 2022-07-06 EP disclosed
CN-114585737-A Oligonucleotide compositions and methods of use thereof 波涛生命科学有限公司 2022-06-03 CN disclosed
WO-2021071858-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2021-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262235-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO ADAR, RNGTT, NSUN2 TYMP 36/4885TYMS 86/4885DUT 32/4885
US-20250135036-A1 COMPOSITIONS FOR EDITING MECP2 TRANSCRIPTS AND METHODS THEREOF MECP2, ADAR, NSUN2 TYMP 1801/4885TYMS 1477/4885DUT 1335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.