Sugi Predict

Sugi Predict / Compounds / SCHEMBL23217006

SCHEMBL23217006

SCHEMBL23217006

COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C(N)=O)c(=O)[nH]c3=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2O)(c2ccc(OC)cc2)c2ccccc2Cc2ccccc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 10/20 0.41
▸ TK2 O00142 2/20 0.38
▸ P2RY14 Q15391 1/20 0.31
▸ SLC5A1 P13866 2/20 0.31
▸ SLC5A2 P31639 2/20 0.31
▸ NT5E P21589 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23216894 0.84 TYMP (0.48) TYMPTK2P2RY14
SCHEMBL23215201 0.83 TYMP (0.46) TYMPTK2
SCHEMBL13714390 0.81 TYMP (0.52) TYMPTK2
SCHEMBL13205006 0.81 TYMP (0.52) TYMPTK2
SCHEMBL3068344 0.81 TYMP (0.52) TYMPTK2
SCHEMBL8535195 0.80 TYMP (0.51) TYMPTK2P2RY14NT5E
SCHEMBL8533223 0.80 TYMP (0.51) TYMPTK2P2RY14NT5E
SCHEMBL29709078 0.79 TYMP (0.44) TYMPNT5E
SCHEMBL17223118 0.77 TYMP (0.51) TYMPP2RY14
SCHEMBL20503186 0.77 TYMP (0.51) TYMPP2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220384-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-07-13 — — US disclosed
EP-4022059-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF Wave Life Sciences Ltd. (SG) 2022-07-06 — — EP disclosed
WO-2021071858-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2021-04-15 — — WO disclosed
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