Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217292 | 0.90 | HTR2A (0.38) | HTR2AHTR2CHTR2BDRD2TNF | |
| SCHEMBL23217313 | 0.88 | HTR2A (0.41) | HTR2AHTR2CHTR2BDRD2TNF | |
| SCHEMBL29967017 | 0.88 | HTR2A (0.41) | HTR2AHTR2CHTR2BDRD2TNF | |
| SCHEMBL23227266 | 0.88 | HTR2A (0.39) | HTR2AHTR2CHTR2BDRD2TNF | |
| Trifluoroacetic Acid SCHEMBL23217044 | 0.87 | DRD2 (0.37) | HTR2AHTR2CHTR2BDRD2KMT2A | |
| Trifluoroacetic Acid SCHEMBL23217047 | 0.87 | DRD2 (0.37) | HTR2AHTR2CHTR2BDRD2KMT2A | |
| SCHEMBL23217461 | 0.87 | HTR2A (0.39) | HTR2AHTR2CHTR2BDRD2KMT2A | |
| SCHEMBL23217321 | 0.87 | HTR2A (0.39) | HTR2AHTR2CHTR2BDRD2KMT2A | |
| SCHEMBL23217201 | 0.84 | HTR2A (0.37) | HTR2AHTR2CHTR2BDRD2CYP2D6 | |
| SCHEMBL23217435 | 0.84 | HTR2C (0.45) | HTR2AHTR2CHTR2BDRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230049231-A1 | ARYL HETEROBICYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-02-16 | — | — | US | disclosed |
| EP-4041405-A1 | ARYL HETEROBICYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. Shaw Research, LLC (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021071832-A1 | ARYL HETEROBICYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230049231-A1 | ARYL HETEROBICYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNB1, KCNJ2, KCNB2 | HTR2A 1799/4885HTR2C 1162/4885HTR2B 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.