Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334055 | 0.90 | MAPK8 (0.40) | PIK3CDPIK3CAMAPK14HRH3HSP90AA1 | |
| SCHEMBL2571086 | 0.90 | PIK3CD (0.50) | PIK3CDPIK3CAMAPK14HRH3HSP90AA1 | |
| SCHEMBL2162687 | 0.86 | HSP90AA1 (0.40) | PIK3CDPIK3CAHRH3HSP90AA1ADORA2A | |
| SCHEMBL2036795 | 0.80 | ADORA2A (0.45) | HRH3HSP90AA1ADORA2AAURKAPRKACA | |
| Hydrochloric Acid SCHEMBL2018276 | 0.78 | ADORA2A (0.44) | HRH3HSP90AA1ADORA2AAURKAPRKACA | |
| SCHEMBL1270087 | 0.77 | HRH4 (0.49) | HRH3HSP90AA1ADORA2AAURKAPRKACA | |
| SCHEMBL28317093 | 0.77 | HRH4 (0.44) | HRH3HSP90AA1ADORA2AAURKAPRKACA | |
| SCHEMBL29979707 | 0.77 | PIK3CD (0.36) | PIK3CDPIK3CAADORA2AMAPK1CHEK1 | |
| SCHEMBL23365116 | 0.77 | PIK3CD (0.36) | PIK3CDPIK3CAADORA2AMAPK1CHEK1 | |
| SCHEMBL1334272 | 0.75 | HRH4 (0.47) | MAPK14HRH3HSP90AA1ADORA2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021072269-A1 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |