Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | SLC26A3 | P40879 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.31 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30010502 | 1.00 | MRGPRX4 (0.33) | MRGPRX4CXCR2SLC26A3MAOBEPHX2 | |
| SCHEMBL21438656 | 0.94 | CXCR2 (0.32) | MRGPRX4CXCR2SLC26A3MAOBEPHX2 | |
| SCHEMBL21438522 | 0.92 | NR1H2 (0.34) | MRGPRX4SLC26A3EPHX2FFAR1FFAR4 | |
| SCHEMBL21438945 | 0.88 | MEN1 (0.32) | MRGPRX4SLC26A3POLBUCHL1 | |
| SCHEMBL21439181 | 0.86 | UCHL1 (0.38) | MRGPRX4EPHX2PPARGPOLBCTDSP1 | |
| SCHEMBL31026075 | 0.84 | MRGPRX4 (0.39) | MRGPRX4SLC26A3MAOBEPHX2PPARG | |
| SCHEMBL30009799 | 0.84 | MRGPRX4 (0.39) | MRGPRX4SLC26A3MAOBEPHX2PPARG | |
| SCHEMBL21438098 | 0.84 | MRGPRX4 (0.39) | MRGPRX4SLC26A3MAOBEPHX2PPARG | |
| SCHEMBL25883833 | 0.84 | FFAR1 (0.33) | MRGPRX4CXCR2MAOBPOLBDUSP3 | |
| SCHEMBL21438494 | 0.83 | CFD (0.38) | MRGPRX4CXCR2MAOBUCHL1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555570-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021072156-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072156-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |