Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150956 | 1.00 | SMO (0.41) | SMOKCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL18150811 | 0.87 | PIK3CA (0.38) | SMOPIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL18151753 | 0.86 | DGAT1 (0.35) | PIK3CBBRD4GPR119 | |
| SCHEMBL18151355 | 0.86 | DGAT1 (0.35) | PIK3CBBRD4GPR119 | |
| SCHEMBL18153272 | 0.85 | AOC3 (0.36) | KCNH2BRD4 | |
| SCHEMBL18151071 | 0.85 | AOC3 (0.36) | KCNH2BRD4 | |
| SCHEMBL18150731 | 0.84 | BRD4 (0.34) | BRD4 | |
| SCHEMBL18151255 | 0.84 | RIPK1 (0.41) | KCNH2OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL18150926 | 0.84 | ABL1 (0.34) | KCNH2PIK3CDPIK3CAPIK3CBBRD4 | |
| SCHEMBL18150738 | 0.84 | AOC3 (0.43) | KCNH2PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072269-A1 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |