Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 6/20 | 0.38 |
| ▸ | F11 | P03951 | 6/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | ACACA | Q13085 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | TPSB2 | P20231 | 3/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218473 | 0.92 | TP53 (0.35) | CFDHDAC1TP53ACACBACACA | |
| SCHEMBL29852424 | 0.92 | TP53 (0.35) | CFDHDAC1TP53ACACBACACA | |
| SCHEMBL16397392 | 0.88 | CFD (0.45) | CFDF11KLKB1HDAC1ACACB | |
| SCHEMBL29852910 | 0.85 | CFD (0.50) | CFDF11KLKB1FFAR1TPSB2 | |
| SCHEMBL23218612 | 0.85 | CFD (0.50) | CFDF11KLKB1FFAR1TPSB2 | |
| SCHEMBL23218268 | 0.81 | BRD4 (0.35) | CFDHDAC1TP53ACACBACACA | |
| SCHEMBL29853071 | 0.81 | BRD4 (0.35) | CFDHDAC1TP53ACACBACACA | |
| SCHEMBL16397602 | 0.81 | BRD4 (0.41) | CFDF11KLKB1HDAC1ACACB | |
| SCHEMBL23218162 | 0.79 | GRM2 (0.36) | CFDHDAC1TP53NR1H2NR1H3 | |
| SCHEMBL23218237 | 0.79 | TP53 (0.36) | CFDHDAC1TP53FFAR1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |