Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 9/20 | 0.49 |
| ▸ | F11 | P03951 | 3/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218760 | 0.91 | CFD (0.54) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL29853224 | 0.91 | CFD (0.54) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL23218107 | 0.88 | CFD (0.61) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL23218888 | 0.86 | CFD (0.47) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL29852896 | 0.86 | CFD (0.43) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL23218288 | 0.86 | CFD (0.43) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL29852722 | 0.84 | CFD (0.47) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL23219073 | 0.84 | CFD (0.47) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL23218858 | 0.84 | CFD (0.54) | CFDF11PLAUTPSB2KLKB1 | |
| SCHEMBL29853271 | 0.84 | CFD (0.54) | CFDF11PLAUTPSB2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |