Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 11/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853115 | 1.00 | CFD (0.40) | CFDPDCD1CD274HSD17B10HTT | |
| SCHEMBL29121917 | 0.91 | CFD (0.42) | CFDHSD17B10HTTALDH1A1CYP1A2 | |
| SCHEMBL29853147 | 0.90 | CFD (0.41) | CFDHSD17B10HTTTBXAS1 | |
| SCHEMBL23218719 | 0.90 | CFD (0.41) | CFDHSD17B10HTTTBXAS1 | |
| SCHEMBL29121623 | 0.89 | CFD (0.41) | CFDHSD17B10HTTALDH1A1CYP1A2 | |
| SCHEMBL29122505 | 0.88 | CFD (0.41) | CFDHSD17B10HTTALDH1A1CYP1A2 | |
| SCHEMBL29123213 | 0.86 | CFD (0.42) | CFDHSD17B10HTTALDH1A1CYP1A2 | |
| SCHEMBL23219250 | 0.85 | CFD (0.39) | CFDPDCD1CD274TBXAS1RET | |
| SCHEMBL29852822 | 0.85 | CFD (0.39) | CFDPDCD1CD274TBXAS1RET | |
| SCHEMBL29122004 | 0.85 | CFD (0.42) | CFDHSD17B10HTTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |