Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852822 | 1.00 | CFD (0.39) | CFDCYP11B1TBXAS1PRMT5HTR1A | |
| SCHEMBL23219087 | 0.90 | CFD (0.48) | CFDTBXAS1PRMT5HTR1ADRD2 | |
| SCHEMBL29852733 | 0.90 | CFD (0.48) | CFDTBXAS1PRMT5HTR1ADRD2 | |
| SCHEMBL29853147 | 0.89 | CFD (0.41) | CFDTBXAS1 | |
| SCHEMBL23218719 | 0.89 | CFD (0.41) | CFDTBXAS1 | |
| SCHEMBL29121929 | 0.88 | CFD (0.40) | CFDTBXAS1 | |
| SCHEMBL23218606 | 0.85 | CFD (0.40) | CFDTBXAS1HTR1ADRD2CD274 | |
| SCHEMBL29853115 | 0.85 | CFD (0.40) | CFDTBXAS1HTR1ADRD2CD274 | |
| SCHEMBL23219205 | 0.85 | CFD (0.41) | CFDTBXAS1 | |
| SCHEMBL29852724 | 0.85 | CFD (0.41) | CFDTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |