Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | FPR1 | P21462 | 2/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853105 | 1.00 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C9USP2 | |
| SCHEMBL23218232 | 0.88 | TSHR (0.40) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL29852543 | 0.88 | TSHR (0.40) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL23218130 | 0.84 | TSHR (0.39) | ALDH1A1CYP1A2CYP3A4CYP2C9HSD17B10 | |
| SCHEMBL23218394 | 0.84 | TSHR (0.38) | ALDH1A1CYP1A2CYP3A4CYP2C9USP2 | |
| SCHEMBL29852953 | 0.83 | TSHR (0.40) | ALDH1A1LMNATSHRKDM4EMEN1 | |
| SCHEMBL23218205 | 0.83 | TSHR (0.40) | ALDH1A1LMNATSHRKDM4EMEN1 | |
| SCHEMBL29852791 | 0.81 | CFD (0.43) | ALDH1A1LMNATSHRKDM4EMEN1 | |
| SCHEMBL23218533 | 0.81 | CFD (0.43) | ALDH1A1LMNATSHRKDM4EMEN1 | |
| SCHEMBL29122740 | 0.80 | TSHR (0.40) | ALDH1A1CYP1A2CYP3A4CYP2C9USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |